National Research Council of Italy

Institute of Biosciences and BioResources

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Nunzia Scotti

Role: Senior Researcher
Section: Researchers and Technologists
Division: Portici
Tel: (39) 081-2539482
E-mail: nunzia.scotti@ibbr.cnr.it

Education

1995 Degree in Biological Sciences, University “Federico II” Naples

1996 Diploma of Dr. Biologist, University “Federico II” Naples

2003 PhD in Molecular Systematic, University “Federico II” Naples

Stage on ‘Innovative molecular technologies to study the expression of potato mitochondrial genome’, Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (2 weeks)

2009 First Course on ‘Research Management’ (1 week), CNR Palermo

2010 Stage on ‘Proteomic analysis of cytoplasmic organelles’, Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (3 weeks)

2023 Habilitation as University full Professor in Plant Genetics

Professional Visits to Other Laboratories

1998 Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (6 weeks), in the framework of CNR-CNRS bilateral Project

1999 Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (three months), in the framework of an EMBO Short Term Fellowship

2000 Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (one month), in the framework of CNR-CNRS bilateral Project

2001 Institut de Biologie Moléculaire des Plantes du CNRS of Strasbourg-France (two months), in the framework of Galileo bilateral Project

2009 Max Plant Institute of Molecular Plant Physiology of Golm-Germany (one month), in the framework of CNR Short Term Mobility

Employment

2001 - october 2020 CNR-IBBR, Research Scientist

october 2020 - present CNR-IBBR, Senior Researcher

Didactics Experience

2002 - 2013 Several lessons on biology and biotechnology of plant cytoplasmic organelles for undergraduate and PhD students, University "Federico II", Naples, Second University of Naples

2011 - 2013 Adjunct Professor, Faculty of Biotechnological Sciences, University "Federico II", Naples, Italy, Course “Production of recombinant proteins in higher plants” (48 hours)

2014 Course "NGS technologies and annotation of plant cytoplasmic genomes" in the framework of the training course for young researcher "Advanced genomic and bioinformatic technologies for plant breeding" (GENOPOM-PRO Project, 20 hours)

Current Research Projects

  • Progetto PON01_01966 “Filiere agro-industriali integrate ad elevata efficienza energetica per la messa a punto di processi di Produzione Eco-compatibili di Energia e Bio-chemicals da fonte rinnovabile e per la valorizzazione del territorio (EnerbioChem) del MIUR
  • Progetto PON02_00395_3082360 “Potenziamento della filiera pomodoro attraverso applicazioni integrate di post-genomica (GenoPOMpro)” del MIUR
  • Progetto PON02_00395_3215002 “Valorizzazione di produzioni ortive campane di eccellenza con strumenti di genomica avanzata (GenHORT) del MIUR
  • Progetto Fondazione con il sud “Produzione di dolcificanti ipocalorici da piante mediterranee”
  • MIUR PON_03 “Sviluppo di tecnologie verdi per la produzione di BIOchemicals per la sintesi e l’applicazione industriale di materiali POLImerici a partire da biomasse vegetali ottenute da sistemi colturali Sostenibili nella Regione Campania” (BioPoliS)
  • Progetto "SVILUPPO DI NUOVE TECNOLOGIE NELL’AGRICOLTURA DI PRECISIONE PER LA PRODUZIONE SOSTENIBILE DI GENOTIPI DI PATATA CON ELEVATE QUALITÀ NUTRIZIONALI" (SOS-TATA), Prog. N. F/200088/01-03/X45 FCS Bando "Horizon 2020", PON I&C 2014-2020
  • Progetto “Sviluppo di alimenti funzionali per l’innovazione dei prodotti alimentari di tradizione italiana (ALIFUN)” PON ARS01_00783
  • Progetto AGRITECH PNRR MUR - M4C2 - Investimento 1.4 - Avviso “Centri Nazionali” - D.D. n. 3138 del 16 dicembre 2021 rettificato con DD n.3175 del 18 dicembre 2021 - CN00000022 “National Research Centre for Agricultural Technologies”, Spoke 1 Plant, animal and microbial genetic resources and adaptation to climatic changes
  • Progetto AGRITECH PNRR MUR - M4C2 - Investimento 1.4 - Avviso “Centri Nazionali” - D.D. n. 3138 del 16 dicembre 2021 rettificato con DD n.3175 del 18 dicembre 2021 - CN00000022 “National Research Centre for Agricultural Technologies”, Spoke 8 Circular economy in agriculture through waste valorization and recycling

Other activities

2002-present Member of the Examining Committee for the recruitment of scientific/technic personel at CNR

2008-present Referee for the following journals: Genome, Plant Biotechnology Journal, Plant Cell Reports, Acta Biochimica et Biophysica Sinica, International Journal of Molecular Sciences, Molecular Breeding, Plant Methods, Transgenic Research, Genes & Genetic Systems

2008 Referee of Research Projects of the Georgian National Science Foundation

2010 Organizes the Annual Meeting of the COST Action FA0804: Molecular Farming -Plants a Production Platform for High Value Proteins, Vico Equense (NA)

2019-present Review Editor of Frontiers in Plant Science, Plant Physiology section

2020-2021 Guest Editor of the Special Issue “Genetics, Genomics and Biotechnology of Plant Cytoplasmic Organelles” in Plants

2021-2022 Guest Editor of the Special Issue “New advances in Plant and Algae Molecular Farming” in International Journal of Molecular Sciences

2022-present CNR Scientific Expert for evaluation and monitoring of Research Projects

Main research topics

Nunzia Scotti is leader of the research group “Genomic and biotechnology of plant cytoplasmic organelles”, working in:

  • Identification of mitochondrial genes underlying cytoplasmic male sterility in potato
  • Genetic variability of tomato and pepper plastid genomes
  • Plastid biotechnology (tobacco and potato)
  • Production of pharmaceutical and industrial proteins in higher plants
  • Identification of chloroplast proteins involved in drought stress in tomato

Publications

Journals

  • Tamburino R, Castiglia D, Marcolongo L, Sannino L, Ionata E, Scotti N. (2022) Tobacco Plastid Transformation as Production Platform of Lytic Polysaccharide MonoOxygenase Auxiliary Enzymes. Int J Mol Sci. 24:309
  • Tamburino R, Marcolongo L, Sannino L, Ionata E, Scotti N. (2022) Plastid Transformation: New Challenges in the Circular Economy Era. Int J Mol Sci. 23:15254
  • Tamburino R, Sannino L, Cafasso D, Cantarella C, Orrù L, Cardi T, Cozzolino S, D’Agostino N, Scotti N. (2020) Cultivated tomato (Solanum lycopersicum) suffered a severe cytoplasmic bottleneck during domestication: implications from chloroplast genomes. Plants 9:1443
  • Varrè JS, D’Agostino N, Touzet P, Gallina S, Tamburino R, Cantarella C, Ubrig E, Cardi T, Drouard L, Gualberto JM, Scotti N. (2019) Complete sequence, multichromosomal architecture and transcriptome analysis of the Solanum tuberosum mitochondrial genome. Int J Mol Sci. 20:4788
  • D’Agostino N, Tamburino R, Cantarella C, De Carluccio V, Sannino L, Cozzolino S, Cardi T, Scotti N. (2018) The complete plastome sequences of eleven Capsicum genotypes:insight into DNA variation and molecular evolution. Genes 9:503
  • Castiglia D., Leone S., Tamburino R., Sannino L., Fonderico J., Melchiorre C., Carpentieri A., Grillo S., Picone D., Scotti N. (2018) High-level production of single chain monellin mutants with enhanced sweetness and stability in tobacco chloroplasts. Planta, doi.org/10.1007/s00425-018-2920-z
  • Tamburino R, Vitale M, Ruggiero A, Sassi M, Sannino L, Arena S, Costa A, Batelli G, Zambrano N, Scaloni A, Grillo S, Scotti N . (2017) Chloroplast proteome response to drought stress and recovery in tomato (Solanum lycopersicum). BMC Plant Biology 17: 40

Books

  • Docimo, T., Scotti, N., Tamburino, R., Villano, C., Carputo, D., D’Amelia, V. (2023). Potato Nutraceuticals: Genomics and Biotechnology for Bio-fortification. In: Kole, C. (eds) Compendium of Crop Genome Designing for Nutraceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-19-3627-2_48-1
  • Tamburino R., Sannino L., Scotti N. (2022) “Il cloroplasto, un organello chiave delle cellule vegetali: dalla biologia alle biotecnologie” in “Recenti progressi nella genetica agraria” ed. G. Corrado, L. Frusciante, IDELSON GNOCCHI. ISBN 978-88-79477901
  • Valkov V., Gargano D., Cardi T., Scotti N. (2021) Plastid Transformation in Potato: An Important Source of Nutrition and Industrial Materials. In: Maliga P (ed) Chloroplast Biotechnology, Methods in Molecular Biology, vol 2317:247-256
  • Cardi T., D’Agostino N., Cantarella C., Colonna V., Greco B., Tamburino R., Taranto F., Scotti N., Tripodi P. (2019) Next generation sequencing technologies for the development of molecular markers and the analysis of genome diversity in Capsicum In: P. Kalaitzis et al. (eds), III International Symposium on Horticulture in Europe- SHE2016, ISHS Acta Horticulturae 1242:831-837, doi:10.17660/ActaHortic.2019.1242.123
  • Rigano M.M., Cardi T., Scotti N. (2014) Le piante come biofabbriche per la produzione di molecole di interesse industriale. In: Rao R. e Leone A. (eds.), Biotecnologie e Genomica delle Piante, Idelson-Gnocchi, Napoli, pp 375-399
  • Cardi T., Aversano R., D’Agostino N., Grillo S., Leone A., Scossa F., Scotti N. (2014) La cellula vegetale e i suoi genomi. In: Rao R. e Leone A. (eds.), Biotecnologie e Genomica delle Piante, Idelson-Gnocchi, Napoli, pp 1-57

  • Valkov V.T., Gargano D., Scotti N., Cardi T. (2014) Plastid transformation in potato: Solanum tuberosum. In: Pal Maliga (ed) Chloroplast Biotechnology, Methods in Molecular Biology, vol. 1132: 295-303, doi: 10.1007/978-1-62703-995-6_18.

  • Scotti N., Rybicki E. P. (2014) Plant-produced virus-like particle vaccines. In: Buonaguro F.M. and Buonaguro L. (eds.) Virus-like particles in vaccine development, Future Science Group eBook (ISBN: 978-1-78084-417-6), pp 102-118, doi: 10.2217/fmeb2013.13.32

  • Scotti N., Bellucci M, Cardi T (2013) The chloroplasts as platform for recombinant proteins production. In: Duchêne A-M (ed) Translation in Mitochondria and Other Organelles. Springer-Verlag, Berlin Heidelberg, pp 225-262, doi: 10.1007/978-3-642-39426-3_10.

  • Cardi T., Giegé P., Kahlau S., Scotti N. (2012) Expression profiling of organellar genes. In: Bock R. & Knoop V. (eds) Genomics of Chloroplasts and Mitochondria, Advances in Photosynthesis and Respiration, vol. 35:323-355, doi: 10.1007/978-94-007-2920-9_14.

  • Scotti N. and Cardi T. (2012) Plastid transformation as an expression tool for plant-derived biopharmaceuticals. In: Jim M. Dunwell and Andy C. Wetten (eds.), Transgenic Plants: Methods and Protocols, Methods in Molecular Biology, vol. 847: 451-466, doi: 10.1007/978-1-61779-558-9_35.

 

Selected Publications

(full list available at CNR People)

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