National Research Council of Italy

Institute of Biosciences and BioResources

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Francesca De Marchis

Role: Researcher
Section: Researchers and Technologists
Division: Perugia
Tel: (39) 075-5014810

Date of birth:17/01/1973

Place of work: Institute of Biosciences and Bioresources (IBBR), CNR, via Madonna Alta 130, 06128 Perugia, Italy

Telephone: 0755014810



  • (July 2012- today) Researcher at IBBR - CNR, via Madonna Alta 130, 06128 Perugia, Italy
  • (2000-2012) research fellow, term contracts at IBBR - CNR, via Madonna Alta 130, 06128 Perugia, Italy. Type of employment or sector: Genetics and Biology and plant biotechnology
  • (1999-2000) Research fellowship at the Experimental Zooprophylactic Institute of Umbria and Marche . Type of employment or sector: production of a vaccine against classical swine fever in plants.


  • (2011-2014) PhD in "Biology and Ecology", University of Perugia
  • (1992-1997) Degree in Biological Sciences, University of Perugia


Genetic, biology and plant biotechnology


- Chloroplast biotechnology

Genetic engineering of tobacco chloroplast in order to accumulate proteins of agronomic, pharmaceutical and industrial interest. Transformation of sugar beet and unicellular alga Chlamydomonas reinhardtii chloroplasts. Studies on the stability of recombinant proteins within the chloroplast and. Exploiting of plastids for the synthesis of vegetable biopolymers of protein origin. Study of alternative selection markers for chloroplast trasformation.

- Non-food crops

Production of proteins for industrial and pharmaceutical use in photosynthetic organisms. Search for vegetable molecules to be used as adjuvants for antibiotic therapy and anti-bacterial biofilm action.

- Protein secretion

Analysis of the different aspects of secretory proteins traffic. Study of the mechanisms that regulate the unconventional trafficking of proteins within the plant cell. Mechanisms that control the synthesis, folding and transport of proteins in the plant cell


From 17 March 2009 to 7 April 2009: Short-term mobility program at the Max Planck Institute of Molecular Plant Physiology - Department of Organelle Biology, Biotechnology and Molecular Ecophysiology, Potsdam, Germany. Research project: "Extraction of proteins from different plastidial compartments"


  • Project of the Italian Ministry of the Environment on genetically modified plants, 2000-2002. (Analysis of the spread of transgenic pollen in fodder legumes)
  • FIRB 2001-2003. (Gene expression and analysis of protein accumulation with an agronomic interest in the plant cell: transcriptional and post-transcriptional mechanisms)
  • EU project "Pharma-Planta", 2004-2007. (Recombinant drugs in plants for human health)
  • EU project "Transcontainer", 2006-2009. (Food quality and safety. Transformation of sugar beet plastome)
  • PRIN 20073YHRLE, 2007-2009. (Protein accumulation and turnover in plant)
  • “Cassa di Risparmio di Perugia” Foundation, project 2012.0197.021, 2012-2013. (Expression of the human alpha-mannosidase enzyme for enzyme replacement therapy of the rare alpha-mannosidosis disease)
  • Project PANN12_00168 (2013) (Dissemination of scientific culture: use of biotechnology for an eco-sustainable future)
  • FARB 2014 Project - University of Perugia (Development of a new plant selection marker for chloroplast transformation)
  • ERC Advanced Grant Project DIDO 338954, 2014-2019 (Innovative drugs targeting IDO molecular dynamics in autoimmunity and neoplasia)
  • Major project, bilateral scientific and technological cooperation of the Minister of Foreign Affairs and International Cooperation PGR05135 (three-year period 2017-2019) (Development of a technological base for the production of clonal seed, Argentina ")
  • European project H2020-MSCA-RISE-2019 (2019-2022) (Mechanisms of apomictic developments)


  • In the organizing committee of the "The Annual Meeting of the European Network for Plant Endomembrane Research (ENPER)", Assisi, Italy, September 16-18, 2011
  • In the organizing committee of the "Unconventional Proteins and Membranes Traffic UPMT meeting" Lecce, Italy, 4-7 October 2016
  • In the local organizing committee of the EMBO Workshop "Molecular mechanisms of unconventional protein secretion in eukaryotic cells" 16-18 September 2019- Assisi
  • Co-editor of the book "UNCONVENTIONAL PROTEIN SECRETION - METHODS AND PROTOCOLS, Springer" Methods and protocols..

Scopus H index: 14

Google scholar H index: 16

Perugia April 2020


Selected Publications

(full list available at CNR People)

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