IBBR Project #281
A microfluidic device to assess the anti-inflammatory effects of ginger-derived nanovesicles on mammalian cells
| Project ID | 281 |
| ID | 15372 |
| Acronym | mEVChip |
| Project acronym and title | A microfluidic device to assess the anti-inflammatory effects of ginger-derived nanovesicles on mammalian cells |
| Contract | CNR-CINVESTAV |
| Description | Extracellular vesicles (EVs) have potential applications in precision medicine, and in the development of next generation cosmeceuticals and nutraceuticals. Generally, the production of EVs from mammalian cells (including mesenchymal cells) is low-yield process, which prompted us to develop and apply new plant-based resources to produce nanometer-sized vesicles. Here, we propose to study ginger-derived nanovesicles (NVs) that has promising health promoting effects. We will also develop a microfluidic platform to evaluate the interaction between NVs and single cells at unprecedented sensitivity and speed. This novel assay uses viable cells trapped and confined in micro wells for assessing cytokine release triggered by the NVs. EVs-MS group (IBBR-CNR) and Bio-ARTS Lab (Cinvestav) will form a truly multidisciplinary team to solve existing gaps in the EV research field and to bring innovative solutions for the two major challenges regarding the isolation and biological characterization of NVs. |
| Funding body | ACCORDI BILATERALI |
| UOS | Napoli |
| Role | Coordinatore |
| Signatory | , Pocsfalvi Gabriella |
| Contact Person | Pocsfalvi Gabriella, José L García-Cordero |
| Starting of activities | 2021 |
| Ending of activities | 2022 |
| Extension | - |
| Amount (euro) | 40000.00 |
| Technological Area | - |
| Technological Field | Nuove frontiere dell’alimentazione |
