Maurizio Tamburrini

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Curriculum Vitae

Date of birth: October 7, 1958

1982. Degree in Biological Sciences.

1983. Awarded a fellowship of the National Research Council of Italy (CNR).

1983 to 1987. Awarded a fellowship for a Research Doctorate Course in Biochemical Sciences, Universities of Naples and Bari, Italy.

1984 to date. Member of the Italian National Biologists Order.

1985 to date. Member of the Italian Society of Biochemistry and Molecular Biology.

1988. Research Doctor in Biochemical Sciences.

1988. Post-doctoral position at the Roche Institute of Molecular Biology, Nutley, New Jersey, USA.

1989 to 1997. Researcher at the CNR Institute of Protein Biochemistry and Enzymology, Naples.

1990-1991 and 1993-1994. Member of the Sixth and of the Ninth Italian Antarctic Expeditions, Terra Nova Bay Scientific Station, Antarctica.

1990 and 1993. Guest Scientist at the New Zealand Scientific Antarctic Station “Scott Base”.

1991. Visiting Investigator at the Leigh Marine Laboratory, University of Auckland, New Zealand.

1992. Member of the Antarctic Expedition ANT X/3, Weddell Sea, Antarctica, on board R/V “Polarstern”, Alfred Wegener Institut, Bremerhaven, Germany.

1997 to 2013. Senior Researcher at the CNR Institute of Protein Biochemistry, Naples.

2014 to date. Senior Researcher at the CNR Institute of Biosciences and BioResources, UOS Naples.

Research interests

Study of the structural and functional properties of food and environmental proteins and peptides, and of their physiological role and impact on human health. Protein purification from the natural sources and identification. Protein characterisation, including elucidation of the primary structure and of post-translational modifications by amino acid sequencing and mass spectrometry, and study of the secondary and tertiary structure by circular dichroism spectroscopy and bioinformatic tools. Functional characterisation, including kinetic studies of enzymatic activities.

Current research topics

• Identification and purification of new allergenic proteins from their natural food or environmental sources.
• Structural and immunological characterisation of the molecules under investigation.
• Analysis of the protein and allergen profile in different foods.
• Stability of specific allergens under different environmental/experimental conditions, including heat stability and gastrointestinal digestion.
• Influence of several factors (ripening stage, post-harvest treatments, cultivar, etc) on the variation of the protein and allergen profiles of plant foods.
• Study of nutraceutical peptides from plant food. Currently our attention is focused on kissper, a peptide isolated from green kiwifruit and showing ion channeling activity in sinthetic membranes, as well as antinflammatory effect on human intestinal cells from patients suffering from Crohn’s disease.

Investigation of the protein biological activities, of their possible effects on human health and of their biomedical application involves collaboration with research groups having appropriate expertise in the fields of 3D-structure determination, physiology and clinics.

Current main collaborations

Prof. Adriano Mari, Associated Centers for Molecular Allergology (CAAM), Rome

(www.caam-allergy.com/)

Prof. Maksymilian Chruszcz, Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA

(www.chem.sc.edu/)

Prof. Delia Picone, Department of Chemical Sciences, University of Naples Federico II, Napoli

(www.docenti.unina.it/delia.picone)

Dr Silvia Pasquariello, C.R.A. Research Unit on Fruit Trees, Caserta

(http://sito.entecra.it/portale/cra_dati_istituto.php?id=233&lingua=EN)

Prof. Carolina Ciacci, Gastrointestinal Unit, Department of Medicine and Surgery, University of Salerno

(www.unisa.it/dipartimenti/dipmedchi/index)

Publications

Please find the full list of my publications at the following URL:

https://scholar.google.it/citations?user=i9u2yxMAAAAJ&hl=it

Selected Publications

(full list available at CNR People)

Toward the valorization of food waste:beneficial effects of tomato Industrial by-Productson the model systemDrosophila melanogaster

Carillo MR, Giangrieco I, Ciardiello MA, Taburrini M, Digilio FA

Year: 2022

Healthy biological activities in legume flours from industrial cooking

Giangrieco I, Tamburrini M, Tuppo L, Pasquariello MS, Ciardiello MA

Year: 2022

Detection of Allergenic Proteins in Foodstuffs: Advantages of the Innovative Multiplex Allergen Microarray-Based Immunoassay Compared to Conventional Methods

Tuppo L, Giangrieco I, Tamburrini M, Alessandri C, Mari A, Ciardiello MA

Year: 2022

Are peas a safe food for lipid transfer protein allergic patients?

Alessandri C, Giangrieco I, Tuppo L, Ferrara R, Zennaro D, Bernardi ML, Ciancamerla M, Rafaiani C, Rafaiani C, Tamburrini M, Mari A, Ciardiello MA

Year: 2021

Pattern of sensitization to Juniperus oxycedrus 4EF-hand polcalcin, Jun o 4, compared with the 2EF-hand grass homolog Phl p 7 in a general Italian population of subjects suffering from pollinosis

Ricciardi T, Giangrieco I, Alessandri C, Rafaiani C, Tuppo L, Tamburrini M, Digilio AF, Ciardiello MA, Mari A

Year: 2021

Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome

Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Tuppo L, Giangrieco I, Ricciardi T, Tamburrini M, Ciardiello MA, Mari A

Year: 2020

ENEA, a peach and apricot IgE-binding protein cross-reacting with the latex major allergen Hev b 5

Giangrieco I, Ricciardi T, Alessandri C, Farina L, Crescenzo R, Tuppo L, Ciancamerla M, Rafaiani C, Bernardi ML, Digilio AF, Cobucci-Ponzano B, Tamburrini M, Mari A, Ciardiello MA

Year: 2019

ENEA, a peach IgE-binding protein cross-reacting with the latex major allergen Hev b 5

Giangrieco I, Ricciardi T, Alessandri C, Tuppo L, Ciancamerla M, Rafaiani C, Tamburrini M, Mari A, Ciardiello MA

Year: 2019

Green kiwifruit extracts protect motor neurons from death in a spinal muscular atrophy model in Caenorhabditis elegans

Mazzarella N, Giangrieco I, Visone S, Santonicola P, Achenbach J, Zampi G, Tamburrini M, Di Schiavi E, Ciardiello MA

Year: 2019

Isolation of cypress gibberellin-regulated protein: analysis of its structural features and IgE binding competition with homologous allergens

Tuppo L, Alessandri C, Giangrieco I, Ciancamerla M, Rafaiani C, Tamburrini M, Ciardiello MA, Mari A

Year: 2019

Different sensitization profiles to mammalian serum albumins as detected by a new IgE detection multiplex assay

Alessandri C, Giangrieco I, Tuppo L, Samolinski B, Emeryk A, Nicolae CA, Miskovic S, Bosotina M, Wu A, Zennaro D, Rafaiani C, Ferrara R, Bernardi ML, Ciancamerla M, Tamburrini M, Majsiak E, Ciardiello MA, Mari, A

Year: 2018

Identification of 2S albumin from pomegranate seeds as an IgE-binding protein

Tuppo L, Alessandri C, Tamburrini M, Giangrieco I, Ricciardi T, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA

Year: 2018

Pomegranate chitinase III: Identification of a new allergen and analysis of sensitization patterns to chitinases

Tuppo L, Giangrieco I, Alessandri C, Ricciardi T, Rafaiani C, Ciancamerla M, Ferrara R, Zennaro D, Bernardi ML, Tamburrini M, Mari A, Ciardiello MA

Year: 2018

Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures

Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Tuppo L, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA

Year: 2017

Multiplex IgE diagnostic test: house dust mite sensitization dissected using six allergenic molecule groups

Alessandri C, Ferrara R, Ml, Bernardi, Zennaro D, Rafaiani C, Ciancamerla M, Tuppo L, Giangrieco I, Tamburrini M, Ciardiello MA, Mari, A

Year: 2017

A multiplex diagnostic test: exploring IgE sensitization to tropomyosins and related sea foods and arthropods

Alessandri C, Giangrieco I, Tuppo L, Bernardi ML, Zennaro D, Ferrara R, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

Multiplex IgE diagnostic test: the most comprehensive view on IgE sensitization to vegetables, fruits and seeds due to lipid transfer proteins

Alessandri C, Giangrieco I, Tuppo L, Ferrara R, Zennaro D, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

Multiplex IgE diagnostic test: the broad view on IgE reactivity to seeds, legumes, nuts, and cereals

Alessandri C, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

FABER IgE diagnostic test: a useful help in understanding IgE sensitization to fishes

Alessandri C, Tuppo L, Giangrieco I, Ferrara R, Bernardi ML, Zennaro D, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

Identification of the IgE-binding protein pommaclein, Pun g 7, in pomegranate fruit

Alessandri C, Tuppo L, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA

Year: 2017

FABER IgE diagnostic test: the most comprehensive view on IgE sensitization to milks and meats

Alessandri C, Tuppo L, Zennaro D, Rafaiani C, Ciancamerla M, Giangrieco I, Ferrara R, Bernardi ML, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

Multiplex IgE diagnostic test: IgE sensitization to furry animal dissected by allergenic molecules and extracts

Alessandri C, Zennaro D, Rafaiani C, Ferrara R, Bernardi ML, Ciancamerla M, Giangrieco I, Tuppo L, Tamburrini M, Ciardiello MA, Mari A

Year: 2017

Multiplex IgE diagnostic test performances compared to singleplex

Mari A, Mitterer G, Rafaiani C, Ciancamerla M, Alessandri C, Bernardi ML, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Tamburrini M, Ciardiello MA, Harwanegg C

Year: 2017

Introducing a multiplex IgE diagnostic test, a new nanobead-based tool for allergy diagnosis: reporting on IgE reactivity of single allergen preparations and reproducibility performances

Mari A, Mitterer G, Rafaiani C, Ciancamerla M, Bernardi ML, Alessandri C, Tuppo L, Giangrieco I, Ferrara R, Zennaro D, Tamburrini M, Ciardiello MA, Harwanegg C

Year: 2017

Faber IgE test: a standard multiplex diagnostic tool to explore allergic sensitization across different European regions: Romania, Croatia, Italy

Miskovic S, Nicolae CA, Grgic P, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Giangrieco I, Tuppo L, Ciardiello MA, Mari A, Alessandri C

Year: 2017

Faber IgE test: A standard multiplex diagnostic tool to explore allergic sensitization across Northern, Central and Southern areas in Italy

Rossi R, Minelli M, Ferrara R, Zennaro D, Bernardi ML, Vergallo I, Maio D, Rafaiani C, Ciancamerla M, Tamburrini M, Tuppo L, Giangrieco I, Ciardiello MA, Mari A, Alessandri C

Year: 2017

Pomegranate Cultivars: Identification of the New IgE-Binding Protein Pommaclein and Analysis of Antioxidant Variability

Tuppo L, Alessandri C, Pasquariello MS, Petriccione M, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA

Year: 2017

Variability of the allergen pattern in different pomegranate cultivars

Tuppo L, Alessandri C, Pasquariello S, Petriccione M, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA

Year: 2017

Influence of geographical location of orchards on green kiwifruit bioactive components

Giangrieco I, Proietti S, Moscatello S, Tuppo L, Battistelli A, La Cara F, Tamburrini M, Famiani F, Ciardiello MA

Year: 2016

Structural features, IgE binding and preliminary clinical findings of the 7kDa Lipid Transfer Protein from tomato seeds

Giangrieco I, Alessandri C, Rafaiani C, Santoro M, Zuzzi S, Tuppo L, Tamburrini M, D’Avino R, Ciardiello MA, Mari A

Year: 2015

Elusive Structural, Functional, and Immunological Features of Act d 5, the Green Kiwifruit Kiwellin

Offermann LR, Giangrieco I, Perdue ML, Zuzzi S, Santoro M, Tamburrini M, Cosgrove DJ, Mari A, Ciardiello MA, Chruszcz M

Year: 2015

The Kiwifruit peptide Kissper displays anti-inflammatory and antioxidant effects in in vitro and ex vivo human intestinal models

Ciacci C, Russo I, Bucci C, Iovino P, Pellegrini L, Giangrieco I, Tamburrini M, Ciardiello MA

Year: 2014

Structure, stability, and IgE binding of the peach allergen Peamaclein (Pru p 7).

Tuppo L, Spadaccini R, Alessandri C, Wienk H, Boelens R, Giangrieco I, Tamburrini M, Mari A, Picone D, Ciardiello MA

Year: 2014