National Research Council of Italy

Institute of Biosciences and BioResources

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Rosa Merlo

Role: research fellow
Section: Contract Staff
Division: Naples
Tel: (39) 081-6132496

Education and Training

2022-present: PostDoc at the Institute of Biosciences and Bioresources (IBBR - UOS Naples)

2021: PhD, University of Naples “Federico II” - Doctorate School in Biology, Naples (Italy)

2016: Master degree in Medical Biotechnologies, LM-9-“MAGISTRALE” DEGREE CLASS IN MEDICAL, PHARMACEUTICAL AND VETERINARY BIOTECHNOLOGIES University of Naples "Federico II", Naples (Italy) with summa cum laude


  • Merlo R.*, Mattossovich R.*, Genta M., Valenti A., Di Mauro G., Minassi A., Miggiano R., Perugino G. First thermostable CLIP-tag by rational design applied to an archaeal O6 -alkyl-guanine-DNA-alkyl-transferase. Comput Struct Biotechnol J. 2022, 20:5275-5286. doi: 10.1016/j.csbj.2022.09.015.
  • Rossetti M., Merlo R., Bagheri N., Moscone D., Valenti A., Saha A., Arantes P.R., Ippodrino R., Ricci F., Treglia I., Delibato E., van der Oost J., Palermo G., Perugino G., Porchetta A. Enhancement of CRISPR/Cas12a trans-cleavage Activity Using Hairpin DNA Reporters. Nucleic Acids Res. 2022, 50:8377-8391. doi: 10.1093/nar/gkac578.
  • Farag N., Mattossovich R., Merlo R., Nierzwicki Ł., Palermo G., Porchetta A., Perugino G., Ricci F. Folding-upon-repair DNA nanoswitches for monitoring DNA repair enzymes activity. Angew Chem Int Ed Engl. 2021, 60:7283-7289. doi: 10.1002/anie.202016223.
  • Merlo R.*, Caprioglio D.*, Cillo M.*, Valenti A., Mattossovich R., Morrone C., Massarotti A., Rossi F., Miggiano R., Leonardi A., Minassi A., Perugino G. The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate. J Enzyme Inhib Med Chem. 2021, 36(1):85-97. doi: 10.1080/14756366.2020.1841182.
  • Mattossovich R.*, Merlo R.*, Miggiano R., Valenti A., Perugino G. O6-alkylguanine-DNA Alkyltransferases in Microbes Living on the Edge: From Stability to Applicability. J. Mol. Sci. 2020, 21(8), 2878.
  • Mattossovich R.*, Merlo R.*, Fontana A., d’Ippolito G., Terns M.P., Watts E.A., Valenti A., Perugino G. A journey down to hell: new thermostable protein-tags for biotechnology at high temperatures. Extremophiles 2020, 24(1):81-91. doi:10.1007/s00792-019-01134-3.
  • Del Prete S.*, Merlo R.*, Valenti A., Mattossovich R., Rossi M., Carginale V., Supuran C.T., Perugino G., Capasso C. Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASLtag). J Enzyme Inhib Med Chem. 2019, 34(1):946-954. doi:10.1080/14756366.2019.1605991.
  • Merlo R.*, Del Prete S.*, Valenti A., Mattossovich R., Carginale V., Supuran C.T., Capasso C., Perugino G. An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane. J Enzyme Inhib Med Chem. 2019, 34(1):490-499. doi:10.1080/14756366.2018.1559161.

    *These authors contributed equally

Selected Publications

(full list available at CNR People)

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