National Research Council of Italy

Institute of Biosciences and BioResources

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F. Anna Digilio

Role: Researcher
Section: Researchers and Technologists
Division: Naples
Tel: (39) 081-6132430

Short CV and Research Activity

In 1985, I graduated from the University of Naples “Federico II”, summa cum laude, with a degree in Biological Sciences; in 1991, I was awarded a PhD in Cellular and Molecular Genetics by the same University. In 1992, I joined the laboratory of John Lucchesi at Emory University in Atlanta (USA), as Visiting Scientist. In 2007-2008 I worked at the CSIC in Madrid, through the program “Estancias de profesores e investigadores extranjeros de acreditata experiencia en centro de invesigationes espanoles”. Since 1989, I have been a CNR Researcher, I lead my own research group, and I have actively participated in a variety of national and international projects, both as principal investigator as well as researcher staff. Since 2009, I have also been involved in science dissemination activities for school teachers and students (CIRED project; school collaboration). Since 2011, I have been honorary fellow in Genetics at the University of Naples Federico II. Since 2011, I have been interested in the application of Quality and Project Management principles to research activity, and I am a founding member of the “qPMO network”. Since 2014, I have been a Researcher at the Institute of Biosciences and BioResources at the CNR of Naples.

Throughout my scientific career, most of my research has revolved around the use of the insect Drosophila melanogaster as model system, with a major interest on studying gene expression regulation during development and differentiation. In particular, from my early work on dosage compensation and gene regulation by the steroid hormone ecdysone, I passed to characterize sex-specific genes in both model and agricultural pest insects. At present, my research activity is focused on two main areas: a) the functional characterization of the male fertility factors in Drosophila and the molecular processes involved in sperm cell differentiation; b) the use of the genetic and transgenic tools of Drosophila melanogaster to uncover the molecular mechanisms of heterologous genes.

I am also interested in this project:


- Furia M., Digilio F.A., Artiaco D., Giordano E., Polito L.C. (1990) A new gene nested within the dunce genetic unit of Drosophila melanogaster. Nucleic Acid Research 18:5837-5841

- Furia M., Digilio F.A., Artiaco D., D’Avino P.P., Cavaliere D., Polito L.C. (1991) Molecular organization of the Drosophila melanogaster Pig-1 gene. Chromosoma, 101: 49-54 .

- Furia M., Digilio F.A., Artiaco D., Favia G., Polito L.C. (1992) Molecular characterization of a D.melanogaster variant strain defective in the Sgs-4 gene dosage compensation. Biochimica et Biophysica Acta 1130, 314-316.

- Furia, M., Giordano, E., Digilio, F.A., Polito, L.C. (1992) A cDNA clone rapresentative of a novel splicing pattern of the Drosophila melanogaster dunce gene. Genetica, 87: 159-163.

- Furia M., D’Avino P.P., Digilio F.A., Crispi S., Giordano E., Polito L.C.(1992) Effect of Ecd1 mutation on the expression of genes mapped at the Drosophila melanogaster 3C11-12 intermolt puff. Genetical Research, 59: 19-26.

- Digilio F.A., Furia M., Capalbo L., Polito L.C. (1993) tosca: un gene ad espressione oocitaria in Drosophila melanogaster. Forme Anno IV, 1: 35-37.

- Digilio F.A., Pannuti A., Lucchesi J.C., Furia M., Polito L.C. (1996) tosca: a Drosophila gene encoding a nuclease specifically expressed in the female germline. Developmental Biology, 178: 90-100.

- Giordano E., Peluso I., Rendina R., Digilio F.A., furia M. (2003) The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily. Mol Genet Genomics. 268:692-697

- Catara G., Ruggiero G., La Cara F., Digilio FA., Capasso A., Rossi M. (2003) A novel extracellular subtilisin-like protease from the hyperthermophile Aeropyrum pernix K1: biochemical properties, cloning, and expression. Extremophiles. 7:391-399.

- Digilio F.A., Morra R., Pedone E., Bartolucci S., Rossi M. (2003) High-level expression of Aliciclobacillus acidocaldarius thioredoxin in Pichia pastoris and Bacillus subtilis. Protein Expr Purif. 30:179-184.

- Di Lauro B., Digilio F.A., Rossi M., Moracci M. (2003) Functional cloning and expression in E. coli of a beta-glycosidase from Alicyclobacillus acidocaldarius. Edited by H.J. Gilbert et al. Recent advances in carbohydrate bioengineering. Cambrideg, UK: Royal Society of Chemistry, 1999.

- Accardo MC., Giordano E., Riccardo S., Digilio FA., Iazzetti G., Calogero RA., Furia M. (2004) A computational search for box C/D snoRNA genes in the D. melanogaster genome. Bioinformatics. 20:3293-301

- Di Cara F., Morra R., Cavaliere D., Sorrentino A., De Simone A., L. Polito L. C., Digilio F.A. (2006) Structure and expression of a novel gene family showing male germline specific expression in Drosophila melanogaster. Insect Molecular Biology, 15:813-822.

- De Simone Anna Maria, Sorrentino Angela, Di Cara Francesca, Polito L.C., Digilio F. Anna (2007). Approaches to identify sex determining genes in the lepidopteronMaruca vitrata. In Iatrou K, Couble P. Journal of Insect Science 7:29.

- Cavaliere D., Di Cara F., Polito L.C.. Digilio F.A. (2009). Cloning and functional characterization of the intersex homologous gene in the pest lepidopteron Maruca vitrata. Int. J. Dev. Biol. 53:1057-1062.

- Di Cara F, Cavaliere D, Galliero V, Polito LC, Digilio FA (2010). Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis. Insect Mol Biol. 19:807-13.

- Scialò F, Hansson BS, Giordano E, Polito CL, Digilio FA (2012) Molecular and functional characterization of the odorant receptor2 (OR2) in the tiger mosquito Aedes albopictus. PLoS One. 7(5):e36538.


Selected Publications

(full list available at CNR People)

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