*

Institute of Biosciences and Bioresources

National Research Council of Italy

Elia Di Schiavi

Role: Researcher
Section: Researchers and Technologists
Division: Naples
Tel: (39) 081-6132365
E-mail: elia.dischiavi@ibbr.cnr.it


Personal Info

Born: 14/10/1974 Naples, Italy
Nationality: Italian
Sex: Male

Professional Address:
Istituto di Bioscienze e Biorisorse - Sezione di Napoli
Via P. Castellino 111
I-80131 Napoli (Italy)

Position: Research Scientist

Main Research Interests

Our group uses the impressive experimental advantages offered by the nematode animal model C. elegans to approach a variety of fundamental biological questions. A major focus of our research is to understand how nervous systems develop, function and react and survive to various insults (a). We also use C. elegans as a model to study in vivo the function played by genes relevant for human health (b) and as a tool in biotechnology (c); these areas are, however, largely interconnected and overlapping in terms of techniques, results, funding and collaborations.

a) C.elegans nervous system is simple and easy to study and to manipulate genetically, but its development and function is remarkably conserved. We have been interested, for example, in avoidance behavior, which is triggered when animals encounter noxious, toxic or repellent stimuli, either produced by plants (e.g. quinine) or by bacteria (e.g from different habitats or pathogenic).

b) We have exploited the extensive conservation of the structure and function of genes and of entire pathways from invertebrates to mammals to study genes whose homologs in humans are involved in diseases.

c) The 1mm size and the 3 days life cycle make C. elegans very attractive as a tool in various biotechnology projects.

- C. elegans is a free living nematode but represents an important model for parasitic ones. We have been interested in finding new targets for the control of plant parasitic nematodes and to set up animal models for screening and validation of new nematocides.

- We are using the disease models we developed to identify and/or validate new molecules capable of slowing down the progression of diseases (e.g Spinal Muscular Atrophy) and to identify chemicals and food contaminants with neurotoxic effects (e.g patulin, chlorpyrifos).

Publication List

Rugarli E.I.*, Di Schiavi E.*, Hilliard M.A., Arbucci S., Ghezzi C., Facciolli A., Coppola G., Ballabio A., Bazzicalupo P.

The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching.

Development. 2002 Mar 1;129(5):1283-1294.

*These two authors contributed equally to this work

Di Schiavi E., Riano E., Heye B., Bazzicalupo P., Rugarli E.I.

UMODL1/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons

European Journal of Neuroscience 2005 Jun 21( 12): 3291-3300

Esposito G.*, Di Schiavi E.*, Bergamasco C., Bazzicalupo P.

Efficient and cell specific knock-down of gene function in targeted C. elegans neurons

Gene. 2007 Jun 15;395(1-2):170-6.

*These two authors contributed equally to this work

Cordeddu V., Di Schiavi E., Pennacchio L.A., Maayan A., Sarkozy A., Cecchetti S., Fodale V., Cardinale A., Zampino G., Mazzanti L., Digilio M.C., Martinelli S., Flex E., Lepri F., Bartholdi D., Kutsche K., Ferrero G.B., Rossi C., Zenker M., Merlo D., Dallapiccola B., Iyengar R., Bazzicalupo P., Gelb B.D. and Tartaglia M.

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.

Nature Genetics 2009 Sep;41(9):1022-6.

Esposito G., Amoroso M.R., Bergamasco C., Di Schiavi E., Bazzicalupo P.

The G Protein regulators EGL-10 and EAT-16, the Giα GOA-1 and the Gqα EGL-30 modulate the response of the C. elegans ASH polymodal nociceptive sensory neurons to repellents.

BMC Biol. 2010 Nov 11;8:138.

Vandamme J., Lettier G., Sidoli S., Di Schiavi E., Nørregaard Jensen O., Salcini A.E.

The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.

PLoS Genet. 2012 May;8(5):e1002647.

Di Schiavi E. and Andrenacci D.

Invertebrate Models of Kallmann Syndrome: Molecular Pathogenesis and New Disease Genes

Current Genomics 2013 Mar; 14(1):2-10 Review

The Network for Central Hypogonadism (Network Ipogonadismo Centrale, NICe) of the Italian Societies of Endocrinology (SIE), of Andrology and Sexual Medicine (SIAMS) and of Peadiatric Endocrinology and Diabetes (SIEDP)

Kallmann’s syndrome and normosmic isolated hypogonadotropic hypogonadism: two largely overlapping manifestations of one rare disorder

J Endocrinol Invest (2014) 37:499-500

E. Flex, M. Jaiswal, F. Pantaleoni, S. Martinelli, M. Strullu, E.K. Fansa, A. Caye, A. De Luca, F. Lepri, R. Dvorsky, L. Pannone, S. Paolacci, S. Zhang, V. Fodale, G. Bocchinfuso, C. Rossi, E.M.M. Burkitt-Wright, A. Farrotti, E. Stellacci, S. Cecchetti, R. Ferese, L. Bottero, S. Castro, O. Fenneteau, B. Brethon, M. Sanchez, A.E. Roberts, H.G. Yntema, I. van der Burgt, P. Cianci, M.L. Bondeson, M.C. Digilio, G. Zampino, B. Kerr, Y. Aoki, M.L. Loh, A. Palleschi, E. Di Schiavi, A. Carè, A. Selicorni, B. Dallapiccola, I.C. Cirstea, L. Stella, M. Zenker, B.D. Gelb, H. Cavé, M.R. Ahmadian & M. Tartaglia,

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

Human Molecular Genetics 2014 Aug 15;23(16):4315-27

F. Ballestriero, M. Daim, A. Penesyan, J. Nappi, D. Schleheck, P. Bazzicalupo, E. Di Schiavi and S. Egan

Antinematode activity of violacein and the role of the insulin/IGF-1 pathway in in controlling violacein sensitivity in Caenorhabditis elegans”.

PLoSONE 2014 Oct 8;9(10):e109201.

 

Selected Publications
(full list available at CNR People)

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