*

Institute of Biosciences and Bioresources

National Research Council of Italy

Alessandra Rogato

Role: Researcher
Section: Researchers and Technologists
Division: Naples
Tel: (39) 081-6132410
E-mail: alessandra.rogato@ibbr.cnr.it


curriculum vitae

Name Alessandra Rogato

Place & date of birth Naples, 08 March 1978

Nationality Italian

Permanent address Via Luigia Sanfelice, 30

80127 Napoli, Italy

Mobile: +393494264273

Lab address Institute of Bioscience and BioResources, CNR,

Via Pietro Castellino 111, 80131 Naples, Italy

Tel.: +39 081 6132 410

Fax: +39 081 6132 706

e-mail alessandra.rogato@ibbr.cnr.it

Current Position

CNR researcher, Institute of Bioscience and Bioresources CNR, No: 14568

Via Pietro Castellino 111, 80131 Naples, Italy

Education

2007: PhD in Advanced Biology, University of Naples Federico II, Italy.

2002: Degree (Master) in Biotechnological Science, University of Naples Federico II, Italy

Professional affiliations and memberships

March 2016- to today: Associate Research at the Department of Integrative Marine Ecology

Stazione Zoologica “A. Dohrn”, Naples, Italy

November 2018 to November 2024: Qualified for the position of Associate Professor 05/A1 (Abilitazione Scientifica Nazionale Bando 2016 (DD n. 1532/2016) (from 06.11.2018 to 06.11.2024).

November 2018 to November 2024: Qualified for the position of Associate Professor in 05/A2 (Abilitazione Scientifica Nazionale Bando 2016 (DD n. 1532/2016) (from 05.11.2018 to 05.11.2024).

Synopsis of research activity

June-July 2014: Visiting Scientist at the Laboratory of Dr. Assaf Vardi at Weizmann Institute of Science. Rehovor, Israel. (CNR Short Term Mobilty Fellow)

November 2011- May 2012: Visiting Scientist at the Laboratory of Dr Angela Falciatore, Dep Diatom Functional Genomics Team,Laboratory of Computational and Quantitative Biology (LCQB), UMR 7238 Université Pierre et Marie Curie, Centre National de la Recherche Scientifique CNRS-UPMC, Paris, France.

2010-2011: CDD chercheur (chercheur à durée déterminée) at Laboratoire de Génomique des Microorganismes/Diatom Functional Genomics Team UMR 7238 Université Pierre et Marie Curie, Centre National de la Recherche Scientifique CNRS-UPMC, Paris, France.

AXA Research Fund, Post-Doctoral Fellowship

2010: Visiting Scientist at the Laboratory of Prof. Dr. Wolfgang Hess. Department: Genetics and Experimental Bioinformatics, University of Freiburg, Germany. Two months

2008-2010: Post-Doctoral research, Stazione Zoologica “A. Dohrn”, Naples, Italy

2007-2008: Post-Doctoral research, Institute of Genetics and Biophysics, ABT, CNR, Naples, Italy

2003-2006: PhD training, Institute of Genetics and Biophysics, ABT, CNR, Naples, Italy.

2002-2003: Post graduated training Institute of Genetics and Biophysics, ABT, CNR, Naples, Italy

2001-2002: Master training at the University of Naples Federico II, Italy.

1999: Erasmus fellowship for developing a research project conducted at the Department of

Plant Biotechnologies, Institute Supérieur Agricole de Beauvais, France.

Research interests

Major objective of my research is to identify and characterize the molecular mechanisms underlying the ecological success of photosyntetic organisms and their capacity for handling different adaptative solutions in order to succeed in a variable environment. In this context, examples of environmental adaptations are the ones that take place in the marine diatoms, which display a suite of sophisticated responses (physiological, biochemical, and behavioral) to optimize their photosynthesis and growth under changing conditions. Marine diatoms are prominent microalgae in the contemporary oceans, several evidences indicated that diatoms dispose of a suite of sophisticated responses to optimize their photosynthesis and growth under changing conditions. However, the molecular mechanisms controlling diatom responses are still largely unknown. I’m trying to integrate genomic and genetic resources, with well-established physiological and biophysical approaches, to characterize light and nutrient regulated processes in diatoms.

I’m mainly focusing on the pathways of uptake and assimilation of N sources and, on the role played by ammonium and nitrate transporters as sensors of the external N conditions in diatoms and in legume plants as well. In addition, I’m involved in a project aiming at deciphering the biogenesis and function of the diatoms silica cell wall (known as the frustule) and exploring his potential physical, optical and biotechnological applications. This is of fundamental importance in the understanding of the interactions of the living cell with the external environment.

Teaching

26 September 2019 European Biotech Week.Lectures title “Molecular secrets from the oceans: marine diatoms”

10 October 2018 Course in Environmental Science for PhD students, University of NaplesFederico II. Lectures title “Molecular secrets from the oceans: marine diatoms”

2014/15, 2015/16, 2016/17 and 2017/18 Course of Marine Microbial Biodiversity, University of Naples Federico II. Lectures on the Biology and Genomics of Diatoms

26 September 2016 European Biotech Week. Lectures title “Molecular secrets from the oceans: marine diatoms”

18 September 2013 Course of "Signal trasduction" for PhD students Open University of London UK at the Stazione Zoologica "A. Dohrn" Napoli.

November 2010 UE NB213: "Biologie du développement des Plantes" M2, Master BIP, UPMC (1er semestre - 6 ECTS). “Light Sensing in the Ocean”

Partecipation and Organization of Courses and Workshops

27 August 2020 Satellite Meeting “Marine Nitrogen-Fixing Symbioses”. Naples- Italy, Organizing Committee

27-31 August 2020 4th European Nitrogen Fixation Conference (ENFC), Naples- Italy, Organizing Committee

14-18 July 2019: EMBO Workshop “The Molecular Life of Diatoms” Paris, France, Selected Poster ( corresponding author)

7-9 June 2017: Workshop “Bringing Maths to Life”. Naples- Italy, Scientific Organiser


19-21 October 2015: Workshop “Bringing Maths to Life”. Naples- Italy, Scientific Organiser


27-29 October 2014: Workshop “Bringing Maths to Life”. Naples- Italy, Scientific Organiser

25-28 June 2013: EMBO Workshop “The Molecular Life of Diatoms” Paris, France, Selected Speaker

July 2012: GerIta Dialogue “Next Generation Sequencing - Application cases and bioinformatics development”, Naples, Italy

9-11 October 2009: EMBO Workshop Evo-Devo meet Marine Ecology, New Frontiers in Ocean Science through Integrative Biology. Sant’Angelo d’Ischia, Italy, EMBO POSTER PRIZE, awarded for outstanding poster presentation


7-11 November 2005: Integral workshop on qRT-PCR. Max Planck Institute, Golm, Germany

Students’ Supervision

Student’s supervisor of five master students and one PhD student

Referee Activity

Reviewer for grants and international journals such as: National Science Foundation (NSF) Division of Ocean Sciences Australian Antarctic Division Science Program, Marine Biotechnology, BMC Genomics, Molecular Biotechnology, Algal Research, Marine Genomics, Journal of Applied Phycology, Plos One, Water, Applied and Environmental Microbiology, Scientific Reports, Journal of Phycology, Applied Sciences, Journal of Marine Research, Marine Drugs (reviewer board; https://www.mdpi.com/journal/marinedrugs/submission_reviewers)

Publications

H-index from Web Google Scholar: 16

H-index from Web of Science: 15

Research articles: 22

Reviews: 4

Books and Journals edited

Spriger Book 2016: “Dynamics of Mathematical Models in Biology, Bringing Mathematics to Life” Editors: Alessandra Rogato, Valeria Zazzu and Mario R Guarracino, ISBN 978-3-319-45722-2

BMC Bioinformatics Special Issue “Proceedings of Bringing Maths to Life (BMTL) 2017”. Supplement Editors: Alessandra Rogato, Laura Antonelli, Vincenza Colonna ISSN: 1471-2105

Marine Drugs Special Issue, "Bioinformatics of Marine Natural Products" (ISSN 1660-3397).

Guest Editors: Alessandra Rogato, Giovanna Romano (in preparation, 2020)

FEMS Microbiology Letters Thematic Issue on “Biological Nitrogen Fixation: genes, organisms, ecosystems” . Editors: Alessandra Rogato; Alessio Mengoni; Roberto Defez; Marco Bazzicalupo; (in preparation, 2020)

Publications

  1. Busseni G., Rocha Jimenez Vieira F., Amato A., Pelletier E., Pierella Karlusich J.J., Ferrante M.I., Winckerd P., Rogato, A., Bowler C.,Sanges R., Maiorano L., Chiurazzi M., Ribera d’Alcalà M., Caputi L., Iudicone D. “Meta-omics reveals genetic flexibility of diatoms nitrogen transporters in response to environmental changes”. Molecular Biology and Evolution, 2019 DOI: 10.1093/molbev/msz157

2.Lauritano C, Ferrante MI, Rogato A. * “Marine natural products from microalgae: an -omics overview”. Marine Drugs 2019, 17(5), 269; Cover of the issue *corresponding author

  1. Sol S., Totev Valkov T., Rogato A, Noguero M., Gargiulo L., Mele G., Lacombe B., Chiurazzi M.

Disruption of the Lotus japonicus transporter LjNPF2. 9 increases shoot biomas...” BMC Plant Niology 2019, 19 (1), 1-14

  1. Rogato A., Del Prete S., Nocentini A., Carginale V., Supuran C.,Capasso C.“Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulfonamide carbonic anhydrase inhibitors”. Journal Of Enzyme Inhibition And Medicinal Chemistry, 2018 ID 1559840; DOI 10.108/14756366.2018.15598
  1. Managò S., Zito G., Rogato A., Casalino M., Esposito E., De Luca A. C., De Tommasi E.

“Bio-derived three-dimensional hierarchical nanostructures as efficient SERS substrates for cell membrane probing” ACS Appl. Mater. Interfaces, 2018. 10, 15, 12406-12416

  1. De Tommasi E, Gielis J, Rogato A. * Diatom Frustule Morphogenesis and Function: a Multidisciplinary Survey”Mar Genomics. 2017 19. pii: S1874-7787(17)30126-5. doi: 10.1016 Cover of the issue *corresponding author
  1. Lepetit B, Gélin G, Lepetit M, Sturm S, Vugrinec S, Rogato A, Kroth PG, Falciatore A, Lavaud J. “The diatom Phaeodactilum tricornutum adjusts nonphotochenical fluorescence quenching capacity in response to dynamic light via fine-tuned Lhcx and xanthophyll cycle pigment synthesis”. New Phytol. 2017 21. doi: 10.1111/nph.14337
  1. Valkov VT, Rogato A., Alves LM, Sol S, Noguero M, Léran S, Lacombe B, Chiurazzi M.

The nitrate transporter family protein NPF8.6 controls the N-fixing nodule act...

Plant Physiol. 2017 pii: pp.01187.2017.

  1. Taddei L*, Stella GR*, Rogato A*, Bailleul B, Fortunato AE, Annunziata R, Sanges R, Thaler M, Lepetit B, Lavaud J, Jaubert M, Finazzi G, Bouly JP, Falciatore A

“Multi-signal control of expression of LHCX protein family in marine diatom Phaeodactylum tricornutum”. J. Exp. Bot. 2016, 67 (13), 3939-3951 doi: 10.1093/jxb/erw198

*co-first author in this publication

  1. Rogato A, Valkov Totev V, Alves L M, Apone F, Colucci G, Chiurazzi M. “Down-regulated Lotus japonicus GCR1 plants exhibit nodulation signalling pathways alteration.” Plant Sci. 2016; 247:71-82. doi: 10.1016
  1. A. Rogato*, A. Amato, D. Iudicone, M. Chiurazzi, M. I. Ferrante , M. Ribera d’Alcalà

“The diatom molecular toolkit to handle nitrogen uptake”. Marine Genomics 2015; 24(1): 95-108 doi: 10.1016 *corresponding author

  1. D’Apuzzo E, Valkov VT, Parlati A, Omrane S, Barbulova A, Sainz MM, Lentini M, Esposito S, Rogato A, Chiurazzi M.”PII Overexpression in Lotus japonicus Affects Nodule Activity in Permissive Lo... Mol Plant Microbe Interact. 2015;28(4):432-42. doi: 10.1094
  2. Rogato A, Richard H, Sarazin A, Voss B, Cheminant Navarro S, Champeimont R, Navarro L, Carbone A, Hess WR, Falciatore A.The diversity of small non-coding RNAs in the diatom Phaeodactylum tricornutum” BMC Genomics 2014; 15(1): 698. DOI: 10.1186/1471-2164-15-698
  3. Lepetit B, Sturm S, Rogato A, Gruber A, Sachse M, Falciatore A, Kroth P, Lavaud J

“High light acclimation in the secondary plastids containing diatom Phaeodactylum tricornutum is triggered by the redox state of the plastoquinone pool”. Plant Physiol, 2013 3: p. 853-86511

  1. Depauw F, Rogato A, Ribera d’Alcalà M and Falciatore A. “Exploring the molecular basis of response to light in marine diatoms”. Journal of Experimental Botany, 2012 63(4):1575-91.
  1. Bailleul B *., Rogato A*., de Martino A., Coesel S., Cardol P., Bowler C., Falciatore A. Finazzi G. “LHCX1 an atypical member of the LHCSR protein family, modulates diatoms response to light”

Proc. Natl. Acad. Sci 2010, 107: 18214-9 *co-first author in this publication

  1. Rogato A., D’Apuzzo E*., Barbulova A., Omrane S., Parlati A., Carfagna S., Costa A., Lo Schiavo F., Esposito S. and Chiurazzi M. “Characterization of a developmental root response caused by external ammonium supply in Lotus japonicus” Plant Physiology 2010, 0: pp.110.160309v1
  1. Rogato A., D’Apuzzo E. and Chiurazzi M. “The multiple plant response to high ammonium condition: the Lotus japonicus AMT1.3 protein acts as a putative transceptor”. Plant Signal Behav. 2010, Dec 1;5 (12)
  1. De Riso V., Raniello R., Maumus F., Rogato A., Bowler C. and Falciatore A. “Gene silencing in the marine diatom Phaeodactylum tricotnutum. Nucleic Acids Res. 2009, 37(14):e96
  1. Coesel S., Mangogna M., Ishikawa T., Heijde M., Rogato A., Finazzi G., Takeshi T., Bowler C.and Falciatore A. “Diatom PtCPF1 is a new cryptochrome/photolyase family member with DNA repair and transcription regulation activity”. EMBO Rep. 2009, 10(6): 655-61
  1. Omrane S., Ferrarini A., D’Apuzzo E., Rogato A., Delledonne M. and Chiurazzi M.

“Symbiotic competence in Lotus japonicus is affected by plant nitrogen status: transcriptomic identification of genes affected by a new signalling pathway”.New Phytol. 2009, 183(2):380-94

  1. Rogato A., D’Apuzzo E., Barbulova A., Omrane S., Stedel C., Rosin U. S.,Katinakis P., Flametakis M., Udvardi M., Chiurazzi M. “Tissue-specific down-regulation of LjAMT1;1 compromises nodule function and enhances nodulation in Lotus japonicus”. Plant Molecular Biology 2008, 68 (6):585-9
  1. Barbulova A., Rogato A., D’Apuzzo E., Omrane S., Chiurazzi M. “Differential effects of combined N sources on early steps of the Nod Factor-Dependent transduction pathways in Lotus japonicus”. Molecular Plant Microbe Interaction 2007, 20(8): 994-1003
  1. Barbulova A., D’Apuzzo E., Rogato A. and Chiurazzi M. “Improved procedures for in vitro regeneration and for phenotypical analysis in the model legume Lotus japonicus”. Functional Plant Biology 2005, 32: 529-536
  1. Ferraioli S., Tatè R., Rogato A., Chiurazzi M. and Patriarca E. J. “Development of ectopic roots from abortive nodule primordia”. Molecular Plant Microbe Interaction 2004, 17: 1043-10
  1. D’Apuzzo E. *, Rogato A*., Simon-Rosin U., El Alaoui H., Barbulova A., Betti M., Dimou M., Katinakis P., Marquez A., Marini A.-M., Udvardi K. M. and Chiurazzi M.“Characterization of three functional high affinity ammonium transporter in Lotus japonicus with differential transcriptional regulation and spatial expression”. Plant Physiology 2004, 134: 1763-1774 *co-first author in this publication

Publications in preparation

  1. Russo, M.T., Rogato, A., Pannone R., Biffali E., Ferrante M.I., De Luca P., Borra M., Mauriello E., Falciatore, A. “Transgene localization in transformed Phaeodactylum tricornutum genome” (In preparation).

Grants

Project Title: BIP BioIndustrial Processess: Founding source: Realizzazione della rete delle biotecnologie campane in attuazione delle azioni a valere e obiettivo operativo 2.1 del POR Campania 2007/2013

Project Title: “Qualità delle produzioni tipiche campane ed il suo territorio: approcci innovativi ed integrati per rafforzare la competitività del sistema Agroalimentare QUARC”. Funding source: CAMPUS per Progetti di Ricerca Industriale e Sviluppo Sperimentale in attuazione degli obiettivi operativi 2.1 e 2.2. del programma operativo FESR Campania 2007/2013 - POR

Project Title: “FaReBio di Qualità -Farmaci e reti Biotecnologiche di Qualità”. Funding source: Italian Ministry of Research and Education (MIUR)

 

Selected Publications
(full list available at CNR People)

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